Comparative genomic analysis reveals varying levels of mammalian adaptation to coronavirus infections

Severe acute respiratory coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, is of zoonotic origin. Evolutionary analyses assessing whether coronaviruses similar to SARSCoV- 2 infected ancestral species of modern-day animal hosts could be useful in identifying additional reservoirs of poten...

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Bibliographic Details
Main Authors:	King, S.B (Author), Singh, M. (Author)
Format:	Article
Language:	English
Published:	Public Library of Science 2021
Subjects:	adaptation Adaptation, Physiological amino acid substitution Amino Acid Substitution angiotensin converting enzyme 2 Angiotensin-Converting Enzyme 2 animal Animals Article binding affinity biology CD13 Antigens cladistics cold common cold Common Cold comparative genomics comparative study Computational Biology controlled study Coronavirus 229E, Human coronavirus disease 2019 Coronavirus infection Coronavirus Infections coronavirus spike glycoprotein COVID-19 Evolution, Molecular evolutionary adaptation genetic selection genetics genomics Genomics Host Microbial Interactions host range Host Specificity host susceptibility human Human coronavirus 229E Humans mammal mammalian genetics Mammals microsomal aminopeptidase molecular evolution molecular phylogeny nonhuman phylogeny Phylogeny physiology primate protein domain protein interaction Protein Interaction Domains and Motifs Receptors, Virus SARS-CoV-2 Selection, Genetic Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein, Coronavirus spike protein, SARS-CoV-2 virology virus entry Virus Internalization virus receptor
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Comparative genomic analysis reveals varying levels of mammalian adaptation to coronavirus infections

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