DNA methylation-based classifier and gene expression signatures detect BRCAness in osteosarcoma

Although osteosarcoma (OS) is a rare cancer, it is the most common primary malignant bone tumor in children and adolescents. BRCAness is a phenotypical trait in tumors with a defect in homologous recombination repair, resembling tumors with inactivation of BRCA1/ 2, rendering these tumors sensitive...

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Bibliographic Details
Main Authors:	Ameline, B. (Author), Barenboim, M. (Author), Baumhoer, D. (Author), Bielack, S. (Author), Burdach, S. (Author), Jones, D.T.W (Author), Kovac, M. (Author), Nathrath, M. (Author), Witt, O. (Author)
Format:	Article
Language:	English
Published:	Public Library of Science 2021
Subjects:	accuracy adolescent adult area under the curve Article Bone Neoplasms bone tumor BRCAness cancer classification child clinical decision making controlled study cross validation differential expression analysis DNA methylation DNA Methylation DNA repair DNA Repair DNA replication down regulation drug sensitivity epigenetics gene expression gene expression regulation Gene Expression Regulation, Neoplastic gene inactivation gene set enrichment analysis genetic regulation genetics genomic instability Genomic Instability genomics homologous recombination human human tissue Humans mismatch repair nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase inhibitor oncological parameters osteosarcoma Osteosarcoma phenotype random forest receiver operating characteristic recombination repair RNA sequence transcriptomics tumor suppressor gene upregulation
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DNA methylation-based classifier and gene expression signatures detect BRCAness in osteosarcoma

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