Inferred expression regulator activities suggest genes mediating cardiometabolic genetic signals

Inferred expression regulator activities suggest genes mediating cardiometabolic genetic signals

Expression QTL (eQTL) analyses have suggested many genes mediating genome-wide association study (GWAS) signals but most GWAS signals still lack compelling explanatory genes. We have leveraged an adipose-specific gene regulatory network to infer expression regulator activities and phenotypic master...

Full description

Bibliographic Details
Main Authors: Amundadottir, L.T (Author), Chung, C.C (Author), Collins, I. (Author), Connelly, K. (Author), Hoskins, J.W (Author), O'Brien, A. (Author), Shi, J. (Author), Zhong, J. (Author)
Format: Article
Language:English
Published: Public Library of Science 2021
Subjects:
algorithm
Article
biological trait
body mass
cardiac muscle
cardiometabolic trait
EPHB2 gene
EPHB2 protein, human
ephrin receptor B2
gene activity
gene expression regulation
gene interaction
gene locus
gene regulatory network
Gene Regulatory Networks
gene targeting
genetic association
genetic procedures
genetic trait
genetic variability
genetics
genome-wide association study
Genome-Wide Association Study
human
human genetics
Humans
metabolism
Myocardium
phenotype
Phenotype
pleiotropy
Polymorphism, Single Nucleotide
prediction
procedures
Quantitative Trait Loci
quantitative trait locus
random forest
Receptor, EphB2
single nucleotide polymorphism
subcutaneous fat
Subcutaneous Fat
transcriptome
Transcriptome
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items