A conserved expression signature predicts growth rate and reveals cell & lineage-specific differences

A conserved expression signature predicts growth rate and reveals cell & lineage-specific differences

Isogenic cells cultured together show heterogeneity in their proliferation rate. To determine the differences between fast and slow-proliferating cells, we developed a method to sort cells by proliferation rate, and performed RNA-seq on slow and fast proliferating subpopulations of pluripotent mouse...

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Bibliographic Details
Main Authors: Badia, M. (Author), Carey, L.B (Author), Generoso, S.F (Author), Jiang, Z. (Author), Payer, B. (Author)
Format: Article
Language:English
Published: Public Library of Science 2021
Subjects:
animal
Animals
cell lineage
Cell Lineage
cell proliferation
Cell Proliferation
cytology
gene expression regulation
Gene Expression Regulation, Developmental
Membrane Potential, Mitochondrial
metabolism
Mice
mitochondrial membrane potential
mouse
mouse embryonic stem cell
Mouse Embryonic Stem Cells
physiology
pluripotent stem cell
Pluripotent Stem Cells
procedures
sequence analysis
Sequence Analysis, RNA
transcriptome
Transcriptome
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