MitoScape: A big-data, machine-learning platform for obtaining mitochondrial DNA from next-generation sequencing data

MitoScape: A big-data, machine-learning platform for obtaining mitochondrial DNA from next-generation sequencing data

The growing number of next-generation sequencing (NGS) data presents a unique opportunity to study the combined impact of mitochondrial and nuclear-encoded genetic variation in complex disease. Mitochondrial DNA variants and in particular, heteroplasmic variants, are critical for determining human d...

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Bibliographic Details
Main Authors: Acheampong, P. (Author), Anderson, S.A (Author), Arany, Z. (Author), Center, R.G (Author), Damrauer, S.M (Author), Emanuel, B.S (Author), Ennis, B. (Author), Li, J. (Author), Loneragan, B. (Author), Potluri, P. (Author), Rader, D.J (Author), Resnick, A.C (Author), Sanchez, M.I.G.L (Author), Singh, L.N (Author), Tran, O. (Author), Trounce, I.A (Author), Tsao, N.L (Author), Wallace, D.C (Author), Zhu, Y. (Author)
Format: Article
Language:English
Published: Public Library of Science 2021
Subjects:
Big Data
DNA, Mitochondrial
Genes, Mitochondrial
genetics
high throughput sequencing
High-Throughput Nucleotide Sequencing
human
Humans
machine learning
Machine Learning
mitochondrial DNA
mitochondrial gene
procedures
Online Access:View Fulltext in Publisher

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