Control of tissue homeostasis, tumorigenesis, and degeneration by coupled bidirectional bistable switches

The Hippo-YAP/TAZ signaling pathway plays a critical role in tissue homeostasis, tumorigenesis, and degeneration disorders. The regulation of YAP/TAZ levels is controlled by a complex regulatory network, where several feedback loops have been identified. However, it remains elusive how these feedbac...

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Bibliographic Details
Main Authors: Avila, D.B (Author), Melendez-Alvarez, J.R (Author), Tian, X.-J (Author)
Format: Article
Language:English
Published: Public Library of Science 2021
Subjects:
Online Access:View Fulltext in Publisher