Identifying proximal RNA interactions from cDNA-encoded crosslinks with ShapeJumper

Identifying proximal RNA interactions from cDNA-encoded crosslinks with ShapeJumper

SHAPE-JuMP is a concise strategy for identifying close-in-space interactions in RNA molecules. Nucleotides in close three-dimensional proximity are crosslinked with a bi-reactive reagent that covalently links the 2’-hydroxyl groups of the ribose moieties. The identities of crosslinked nucleotides ar...

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Bibliographic Details
Main Authors: Christy, T.W (Author), Giannetti, C.A (Author), Laederach, A. (Author), Weeks, K.M (Author)
Format: Article
Language:English
Published: Public Library of Science 2021
Subjects:
algorithm
Algorithms
Article
binding site
Binding Sites
bioinformatics
biology
chemistry
complementary DNA
Computational Biology
conformation
controlled study
cross linking reagent
Cross-Linking Reagents
DNA cross linking
DNA, Complementary
gene interaction
gene sequence
genetic engineering
Genetic Engineering
genetic procedures
genetics
Models, Molecular
molecular interaction
molecular model
nucleic acid analysis
Nucleic Acid Conformation
reverse transcription
RNA
RNA analysis
sequence alignment
Sequence Alignment
software
Software
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Internet

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