Dynamic optimization reveals alveolar epithelial cells as key mediators of host defense in invasive aspergillosis

Dynamic optimization reveals alveolar epithelial cells as key mediators of host defense in invasive aspergillosis

Aspergillus fumigatus is an important human fungal pathogen and its conidia are constantly inhaled by humans. In immunocompromised individuals, conidia can grow out as hyphae that damage lung epithelium. The resulting invasive aspergillosis is associated with devastating mortality rates. Since infec...

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Bibliographic Details
Main Authors: Brakhage, A.A (Author), Ewald, J. (Author), Kaleta, C. (Author), Radosa, L. (Author), Rivieccio, F. (Author), Schuster, S. (Author)
Format: Article
Language:English
Published: Public Library of Science 2021
Subjects:
Alveolar Epithelial Cells
animal
Animals
Article
aspergillosis
Aspergillosis
Aspergillus fumigatus
biological model
biology
C57BL mouse
cell culture
cell function
cell line
Cells, Cultured
clinical protocol
Computational Biology
computer model
conidium
cytokine release
female
Female
fungal spore germination
fungal virulence
fungus growth
fungus spore
host pathogen interaction
host resistance
Host-Pathogen Interactions
human
Humans
immune response
Immunity, Innate
immunology
in vitro study
infectious agent
innate immunity
invasive aspergillosis
lung alveolus epithelium cell
lung alveolus macrophage
male
Male
Mice
Mice, Inbred C57BL
Models, Immunological
mouse
neutrophil
Neutrophils
nonhuman
prediction
Spores, Fungal
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