Multifunctional RNA-binding proteins influence mRNA abundance and translational efficiency of distinct sets of target genes

RNA-binding proteins (RBPs) can regulate more than a single aspect of RNA metabolism. We searched for such previously undiscovered multifunctionality within a set of 143 RBPs, by defining the predictive value of RBP abundance for the transcription and translation levels of known RBP target genes acr...

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Bibliographic Details
Main Authors:	Hubner, N. (Author), Ruiz-Orera, J. (Author), Schneider-Lunitz, V. (Author), vanHeesch, S. (Author)
Format:	Article
Language:	English
Published:	Public Library of Science 2021
Subjects:	5' untranslated region Article BCLAF1 protein binding affinity biology cardiac muscle cohort analysis Computational Biology computer model controlled study cytology DDX3X protein DDX42 protein DDX6 protein DROSHA protein EFTUD2 protein FAM120A protein FASTKD2 protein G3BP1 protein GEMIN5 protein gene expression gene expression regulation Gene Expression Regulation genetics HNRNPM protein human human cell human tissue Humans in vivo study messenger RNA metabolism Myocardium NKRF protein NOLC1 protein Protein Biosynthesis protein synthesis PRPF8 protein PUM1 protein RBM22 protein RNA binding protein RNA translation RNA, Messenger RNA-Binding Proteins SRSF1 protein SRSF7 protein TRA2A protein translation regulation U2AF2 protein UCHL5 protein unclassified drug
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Multifunctional RNA-binding proteins influence mRNA abundance and translational efficiency of distinct sets of target genes

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