Roles of mTOR in thoracic aortopathy understood by complex intracellular signaling interactions

Roles of mTOR in thoracic aortopathy understood by complex intracellular signaling interactions

Thoracic aortopathy–aneurysm, dissection, and rupture–is increasingly responsible for significant morbidity and mortality. Advances in medical genetics and imaging have improved diagnosis and thus enabled earlier prophylactic surgical intervention in many cases. There remains a pressing need, howeve...

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Bibliographic Details
Main Authors: Estrada, A.C (Author), Humphrey, J.D (Author), Irons, L. (Author), Li, G. (Author), Rego, B.V (Author), Tellides, G. (Author)
Format: Article
Language:English
Published: Public Library of Science 2021
Subjects:
Akt signaling
animal
animal cell
animal experiment
animal model
Animals
aortic aneurysm
Aortic Aneurysm
aortic disease
apoptosis
Article
cell proliferation
controlled study
degradation
genetics
human
Humans
intracellular signaling
male
Male
mammalian target of rapamycin
metabolism
Mice
mouse
MTOR protein, human
mTOR protein, mouse
Myocytes, Smooth Muscle
nonhuman
phenotype
positive feedback
proteomics
qualitative analysis
quantitative analysis
rapamycin
signal transduction
Signal Transduction
simulation
smooth muscle cell
target of rapamycin kinase
thoracic aorta
thoracic aortopathy
TOR Serine-Threonine Kinases
wild type
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