Allostery in the dynamic coactivator domain KIX occurs through minor conformational micro-states
The coactivator KIX of CBP uses two binding surfaces to recognize multiple activators and exhibits allostery in ternary complex formation. Activator•coactivator interactions are central to transcriptional regulation, yet the microscopic origins of allostery in dynamic proteins like KIX are largely u...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science
2022
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| Subjects: | |
| Online Access: | View Fulltext in Publisher |