Distinguishing excess mutations and increased cell death based on variant allele frequencies
Tumors often harbor orders of magnitude more mutations than healthy tissues. The increased number of mutations may be due to an elevated mutation rate or frequent cell death and correspondingly rapid cell turnover, or a combination of the two. It is difficult to disentangle these two mechanisms base...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science
2022
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| Subjects: | |
| Online Access: | View Fulltext in Publisher |