A comparison of assays for accurate copy number measurement of the low-affinity FC gamma receptor genes FCGR3A and FCGR3B

A comparison of assays for accurate copy number measurement of the low-affinity FC gamma receptor genes FCGR3A and FCGR3B

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The FCGR3 locus encoding the low affinity activating receptor FcγRIII, plays a vital role in immunity triggered by cellular effector and regulatory functions. Copy number of the genes FCGR3A and FCGR3B has previously been reported to affect susceptibility to several autoimmune diseases and chronic i...

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Bibliographic Details
Main Authors: Abubakar, S. (Author), Aziz, A.T.A (Author), Bakar, S.A (Author), Haridan, U.S (Author), Hollox, E.J (Author), Lee, C.K.C (Author), Machado, L.R (Author), Mokhtar, U. (Author), Mustafa, M. (Author), Peng, H.B (Author), Shueb, R.H (Author), Sim, B. (Author), Yusof, N.K.N (Author), Zaid, M. (Author)
Format: Article
Language:English
Published: Public Library of Science 2015
Subjects:
allele
Article
bioassay
Biological Assay
case control study
Case-Control Studies
controlled study
copy number variation
dengue
Dengue
DNA Copy Number Variations
Fc receptor
FCGR3A gene
FCGR3A protein, human
FCGR3B gene
FCGR3B protein, human
gene
gene dosage
genetic association
genetic parameters
genetic predisposition
Genetic Predisposition to Disease
genetic variability
genetics
genotype
Genotype
glycosylphosphatidylinositol anchored protein
GPI-Linked Proteins
human
Humans
measurement accuracy
paralogue ratio test restriction enzyme digest variant ratio
procedures
quantitative analysis
real time polymerase chain reaction
Real-Time Polymerase Chain Reaction
Receptors, IgG
sequence homology
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