Fucoidan extracts ameliorate acute colitis

Inflammatory bowel diseases (IBD), such as ulcerative colitis and Crohn's disease, are an important cause of morbidity and impact significantly on quality of life. Overall, current treatments do not sustain a long-term clinical remission and are associated with adverse effects, which highlight...

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Bibliographic Details
Main Authors:	Eri, R.D (Author), Fitton, J.H (Author), Gueven, N. (Author), Lean, Q.Y (Author), Patel, R.P (Author)
Format:	Article
Language:	English
Published:	Public Library of Science 2015
Subjects:	acute disease Acute Disease Administration, Oral animal animal experiment animal model animal tissue Animals antiinflammatory activity Article body weight Body Weight C57BL mouse cell infiltration chemically induced chemistry colitis Colitis colon Colon controlled study cytokine cytokine production Cytokines depyrogenated fucoidan dextran sulfate Dextran Sulfate diarrhea disease model Disease Models, Animal drug effect drug effects edema eotaxin fucoidan polyphenol complex fucoidin Fucus gamma interferon goblet cell granulocyte colony stimulating factor granulocyte macrophage colony stimulating factor histopathology immunocompetent cell immunology interleukin 10 interleukin 12p40 interleukin 12p70 interleukin 13 interleukin 1alpha interleukin 1beta interleukin 3 intestine crypt macrophage inflammatory protein 1alpha macrophage inflammatory protein 1beta male Male metabolism Mice Mice, Inbred C57BL mouse Mus neutrophil chemotaxis Neutrophil Infiltration nonhuman oral drug administration pathology Phaeophyceae physiology plant extract Plant Extracts polyphenol Polyphenols polysaccharide Polysaccharides RANTES rectum hemorrhage spleen Spleen spleen weight tumor necrosis factor alpha unclassified drug
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Fucoidan extracts ameliorate acute colitis

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