Orally Administered Enoxaparin Ameliorates Acute Colitis by Reducing Macrophage-Associated Inflammatory Responses

Orally Administered Enoxaparin Ameliorates Acute Colitis by Reducing Macrophage-Associated Inflammatory Responses

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Inflammatory bowel diseases, such as ulcerative colitis, cause significant morbidity and decreased quality of life. The currently available treatments are not effective in all patients, can be expensive and have potential to cause severe side effects. This prompts the need for new treatment modaliti...

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Bibliographic Details
Main Authors: Eri, R.D (Author), Gueven, N. (Author), Lean, Q.Y (Author), Patel, R.P (Author), Peterson, G.M (Author), Randall-Demllo, S. (Author), Sohal, S.S (Author), Stewart, N. (Author)
Format: Article
Language:English
Published: Public Library of Science 2015
Subjects:
acute disease
Acute Disease
animal
animal experiment
animal model
animal tissue
Animals
anticoagulant agent
Anticoagulants
antiinflammatory agent
Anti-Inflammatory Agents
Article
C57BL mouse
cell count
cell differentiation
chemically induced
claudin 4
colitis
Colitis
colon injury
colon weight
controlled study
crypt cell
cytokine
Cytokines
dextran sulfate
Dextran Sulfate
diarrhea
disease model
Disease Models, Animal
drug effect
drug effects
drug efficacy
drug mechanism
edema
enoxaparin
Enoxaparin
enzyme immunoassay
granulocyte colony stimulating factor
granulocyte macrophage colony stimulating factor
histopathology
Immunoenzyme Techniques
immunohistochemistry
immunology
inflammation
Inflammation
interleukin 10
interleukin 1alpha
interleukin 1beta
lymphocytic infiltration
macrophage
macrophage inflammatory protein 1alpha
macrophage inflammatory protein 1beta
Macrophages
male
Male
metabolism
Mice
Mice, Inbred C57BL
mouse
nonhuman
occludin
occult blood
organ weight
pathology
protein blood level
Weight Loss
weight reduction
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