Detection of CYP2C19 genetic variants in Malaysian Orang Asli from massively parallel sequencing data

Detection of CYP2C19 genetic variants in Malaysian Orang Asli from massively parallel sequencing data

The human cytochrome P450 (CYP) is a superfamily of enzymes that have been a focus in research for decades due to their prominent role in drug metabolism. CYP2C is one of the major subfamilies which metabolize more than 10% of all clinically used drugs. In the context of CYP2C19, several key genetic...

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Bibliographic Details
Main Authors: Ahmad, A. (Author), Ang, G.Y (Author), Aziz, T.A.T.A (Author), Isa, K.M (Author), Ismail, A.I (Author), James, R.J (Author), Khalid, M.I.H.A (Author), Nor, F.M (Author), Rahman, T.A (Author), Salleh, H. (Author), Salleh, M.Z (Author), Subramaniam, V. (Author), Teh, L.K (Author), Yu, C.Y (Author)
Format: Article
Language:English
Published: Public Library of Science 2016
Subjects:
adolescent
Adolescent
adult
Adult
aged
Aged
allele
Alleles
Article
Asian continental ancestry group
Asian Continental Ancestry Group
biotechnology
CYP2C19 gene
cytochrome P450 2C19
Cytochrome P-450 CYP2C19
exon
female
Female
gene amplification
gene frequency
gene function
gene identification
gene linkage disequilibrium
gene sequence
genetic variability
genetic variation
Genetic Variation
genetics
genotype
Genotype
haplotype
Haplotypes
high throughput sequencing
High-Throughput Nucleotide Sequencing
human
human experiment
Humans
intron
Linkage Disequilibrium
Malaysia
male
Male
middle aged
Middle Aged
normal human
null allele
Orang Asli
pharmacogenomics
Polymorphism, Single Nucleotide
population genetics
single nucleotide polymorphism
young adult
Young Adult
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