Reduction of oxidative-nitrosative stress underlies anticataract effect of topically applied tocotrienol in streptozotocin-induced diabetic rats

Reduction of oxidative-nitrosative stress underlies anticataract effect of topically applied tocotrienol in streptozotocin-induced diabetic rats

Cataract, a leading cause of blindness, is of special concern in diabetics as it occurs at earlier onset. Polyol accumulation and increased oxidative-nitrosative stress in cataractogenesis are associated with NFκB activation, iNOS expression, ATP depletion, loss of ATPase functions, calpain activati...

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Bibliographic Details
Main Authors: Agarwal, R. (Author), Daher, A.M (Author), Ibrahim, M.I (Author), Iezhitsa, I. (Author), Ismail, N.M (Author), Kadir, S.H.S.A (Author), Nasir, N.A.A (Author), Tripathy, M. (Author), Vasudevan, S. (Author)
Format: Article
Language:English
Published: Public Library of Science 2017
Subjects:
adenosine triphosphatase
Adenosine Triphosphatases
adenosine triphosphate
Adenosine Triphosphate
Administration, Topical
aldehyde reductase
alpha tocotrienol
animal
animal experiment
animal model
animal tissue
Animals
antioxidant
antioxidant activity
Antioxidants
Article
blood
Blood Glucose
body weight
Body Weight
calpain
Calpain
calpain 2
Capn2 protein, rat
catalase
Catalase
cataract
Cataract
complication
controlled study
Diabetes Mellitus, Experimental
drug effects
enzyme activity
experimental diabetes mellitus
gene expression
Gene Expression
genetics
glucose blood level
glutathione
Glutathione
hyperglycemia
immunoglobulin enhancer binding protein
inducible nitric oxide synthase
lens
Lens, Crystalline
male
Male
metabolism
NF-kappa B
Nitric Oxide Synthase Type II
nitrosation
Nitrosation
nitrosative stress
nonhuman
oxidative stress
Oxidative Stress
pathology
Pilot Projects
pilot study
polyol
protein expression
rat
Rats, Sprague-Dawley
sorbitol
Sprague Dawley rat
streptozotocin-induced diabetes mellitus
superoxide dismutase
Superoxide Dismutase
time factor
Time Factors
Tocotrienols
topical drug administration
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