Triazoloquinazolines as a new class of potent α-glucosidase inhibitors: In vitro evaluation and docking study

Triazoloquinazolines as a new class of potent α-glucosidase inhibitors: In vitro evaluation and docking study

Previously, we synthesized triazoloquinazolines 1-14 and characterized their structure. In this study, we aimed to evaluate the in vitro activity of the targets 1-14 as α-glucosidase inhibitors using α-glucosidase enzyme from Saccharomyces cerevisiae type 1. Among the tested compounds, triazoloquina...

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Bibliographic Details
Main Authors: Abuelizz, H.A (Author), Ahmad, R. (Author), Al-Salahi, R. (Author), Anouar, E.H (Author), Marzouk, M. (Author), Nor Azman, N.I.I (Author)
Format: Article
Language:English
Published: Public Library of Science 2019
Subjects:
acarbose
alpha glucosidase
alpha glucosidase inhibitor
alpha-Glucosidases
Article
chemical structure
controlled study
drug potency
drug structure
drug synthesis
enzyme active site
enzyme inhibition
enzyme inhibitor interaction
glycosidase inhibitor
Glycoside Hydrolase Inhibitors
IC50
in vitro study
metabolism
molecular docking
Molecular Docking Simulation
Molecular Structure
nonhuman
quinazoline derivative
Quinazolines
Saccharomyces cerevisiae
structure activity relation
Structure-Activity Relationship
triazole derivative
Triazoles
triazoloquinazoline
triazoloquinazoline derivative
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