Combined PCR and MAT improves the early diagnosis of the biphasic illness leptospirosis

The diagnosis of leptospirosis remains a challenge due to its non-specific symptoms and the biphasic nature of the illness. A comprehensive diagnosis that includes both molecular (polymerase chain reaction (PCR)) and serology is vital for early detection of leptospirosis and to avoid misdiagnosis. H...

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Bibliographic Details
Main Authors:	Affendy, N.B (Author), Masri, S.N (Author), Muhamad, Y.Y (Author), Neela, V.K (Author), Philip, N. (Author), Sekawi, Z. (Author), Than, L.T.L (Author)
Format:	Article
Language:	English
Published:	Public Library of Science, 2020
Subjects:	agglutination test Agglutination Tests arthralgia Article bacterial DNA blood blood analysis blood sampling clinical feature clinical trial controlled study diagnostic error Diagnostic Errors DNA 16S DNA extraction DNA, Bacterial early diagnosis Early Diagnosis enzyme linked immunosorbent assay Feasibility Studies feasibility study genetics headache human Humans immunology informed consent isolation and purification Leptospira leptospirosis Leptospirosis Malaysia microbiology microscopic agglutination test molecular diagnosis molecular dynamics multicenter study myalgia nonhuman polymerase chain reaction Polymerase Chain Reaction predictive value prevention and control RNA 16S RNA, Ribosomal, 16S sensitivity and specificity Sensitivity and Specificity sepsis Sepsis seroconversion serology time factor Time Factors
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Combined PCR and MAT improves the early diagnosis of the biphasic illness leptospirosis

Internet

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