Ischemia and reperfusion injury to mitochondria and cardiac function in donation after circulatory death hearts - An experimental study

Ischemia and reperfusion injury to mitochondria and cardiac function in donation after circulatory death hearts - An experimental study

The ultimate treatment for patients with end-stage heart failure is heart transplantation. The number of donor hearts which are primarily procured from donation after brain death (DBD) donors is limited, but donation after circulatory death (DCD) donor hearts can increase the heart donor pool. Howev...

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Bibliographic Details
Main Authors: Akande, O. (Author), Chen, Q. (Author), Lesnefsky, E.J (Author), Quader, M. (Author), Toldo, S. (Author)
Format: Article
Language:English
Published: Public Library of Science 2021
Subjects:
animal
animal experiment
animal model
Animals
Article
brain death
Brain Death
calcium
Calcium
calcium ion
controlled study
disorders of mitochondrial functions
donor
experimental study
heart
Heart
heart contraction
heart death
heart function
heart left ventricle function
heart mitochondrion
heart muscle relaxation
heart muscle reperfusion
heart rate
Heart Rate
heart transplantation
Heart Transplantation
hydrogen peroxide
Hydrogen Peroxide
in vitro study
in vivo study
inotropy
ischemia
lusitropy
male
Male
metabolism
Mitochondria
mitochondrion
Myocardial Contraction
myocardial ischemia reperfusion injury
non heart beating donor
nonhuman
oxidative phosphorylation
Oxidative Phosphorylation
physiology
procedures
rat
Rats
Rats, Sprague-Dawley
reperfusion injury
Reperfusion Injury
Sprague Dawley rat
time factor
Time Factors
Tissue and Organ Procurement
Tissue Donors
transplantation
Ventricular Function, Left
Warm Ischemia
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