Metabolic memory underlying minimal residual disease in breast cancer

Metabolic memory underlying minimal residual disease in breast cancer

Tumor relapse from treatment-resistant cells (minimal residual disease, MRD) underlies most breast cancer-related deaths. Yet, the molecular characteristics defining their malignancy have largely remained elusive. Here, we integrated multi-omics data from a tractable organoid system with a metabolic...

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Bibliographic Details
Main Authors: Alladin, A. (Author), Brügger, B. (Author), Gawrzak, S. (Author), Jechlinger, M. (Author), Kafkia, E. (Author), Lüchtenborg, C. (Author), Machado, D. (Author), Patil, K.R (Author), Radic Shechter, K. (Author), Sévin, D.C (Author), Zirngibl, K. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2021
Subjects:
animal
animal experiment
Animals
Article
breast cancer
Breast Neoplasms
breast tumor
cell population
controlled study
DNA methylation
doxycycline
epigenetics
female
Female
genetics
glycolysis
human
human tissue
Humans
memory
metabolic modeling
Mice
minimal residual disease
mouse
multi-omics integration
Neoplasm Recurrence, Local
Neoplasm, Residual
nonhuman
oncogenic memory
organoids
pathophysiology
phenotype
transcriptomics
tumor recurrence
urea cycle
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