Synthesis, spectral analysis and pharmacological study of N’-substituted-2-(5-((2,4-dimethylphenoxy)methyl)-1,3,4-oxadiazol-2-ylthio)acetohydrazides

A series of molecules bearing multiple functional groups were synthesized to study their antibiotic effect against Gram-positive and Gram-negative bacteria and lipoxygenase activity as well. 2,4-Dimethylcarbolic acid (1) was refluxed with ethyl 2-bromoacetate to synthesize ethyl 2-(2,4-dimethylpheno...

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Bibliographic Details
Main Authors:	Abbasi, M.A (Author), Aziz-ur-Rehman (Author), Rasool, S. (Author), Shah, S.A.A (Author), Siddiqui, S.Z (Author)
Format:	Article
Language:	English
Published:	Faculdade de Ciencias Farmaceuticas (Biblioteca) 2016
Subjects:	1,3,4 oxadiazole derivative 2,4 dimethylcarbolic acid 5 [(2,4 dimethylphenoxy)methyl] 1,3,4 oxadiazol 2 thiol acetic acid Acetohydrazides/antibacterial activity/acetohydrazides/lipoxygenase/inhibition activity Acetohydrazides/synthesis antibacterial activity Article azomethine ylide Bacillus subtilis baicalein controlled study drug structure drug synthesis enzyme inhibition Escherichia coli ether ethyl 2 (2,4 dimethylphenoxy)acetate ethyl 2 bromoacetate hydrazide hydrazone derivative infrared spectroscopy lipoxygenase mass spectrometry methanol minimum inhibitory concentration n' (2 hydroxybenzylidene) 2 [5 [(2,4 dimethylphenoxy)methyl] 1,3,4 oxadiazol 2 ylthio]acetohydrazide n' (2 methylbenzylidene) 2 [5 [(2,4 dimethylphenoxy)methyl] 1,3,4 oxadiazol 2 ylthio]acetohydrazide n' (2 nitrobenzylidene) 2 [5 [(2,4 dimethylphenoxy)methyl] 1,3,4 oxadiazol 2 ylthio]acetohydrazide n' (3 hydroxybenzylidene) 2 [5 [(2,4 dimethylphenoxy)methyl] 1,3,4 oxadiazol 2 ylthio]acetohydrazide n' (3 methylbenzylidene) 2 [5 [(2,4 dimethylphenoxy)methyl] 1,3,4 oxadiazol 2 ylthio]acetohydrazide n' (3 nitrobenzylidene) 2 [5 [(2,4 dimethylphenoxy)methyl] 1,3,4 oxadiazol 2 ylthio]acetohydrazide n' (4 hydroxybenzylidene) 2 [5 [(2,4 dimethylphenoxy)methyl] 1,3,4 oxadiazol 2 ylthio]acetohydrazide n' (4 methoxybenzylidene) 2 [5 [(2,4 dimethylphenoxy)methyl] 1,3,4 oxadiazol 2 ylthio]acetohydrazide n' (4 methylbenzylidene) 2 [5 [(2,4 dimethylphenoxy)methyl] 1,3,4 oxadiazol 2 ylthio]acetohydrazide n' (4 nitrobenzylidene) 2 [5 [(2,4 dimethylphenoxy)methyl] 1,3,4 oxadiazol 2 ylthio]acetohydrazide n' [4 (diethylamino)benzylidene] 2 [5 [(2,4 dimethylphenoxy)methyl] 1,3,4 oxadiazol 2 ylthio]acetohydrazide n' [4 (dimethylamino)benzylidene] 2 [5 [(2,4 dimethylphenoxy)methyl] 1,3,4 oxadiazol 2 ylthio]acetohydrazide n' 2 [5 [(2,4 dimethylphenoxy)methyl] 1,3,4 oxadiazol 2 ylthio]acetohydrazide derivative n' benzylidene 2 [5 [(2,4 dimethylphenoxy)methyl] 1,3,4 oxadiazol 2 ylthio]acetohydrazide nonhuman phenol proton nuclear magnetic resonance Pseudomonas aeruginosa room temperature Salmonella enterica serovar Typhi Staphylococcus aureus thiol unclassified drug
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Synthesis, spectral analysis and pharmacological study of N’-substituted-2-(5-((2,4-dimethylphenoxy)methyl)-1,3,4-oxadiazol-2-ylthio)acetohydrazides

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