Synthesis and in silico study of 2-furyl(4-{4-[(substituted)sulfonyl]benzyl}-1-piperazinyl)methanone derivatives as suitable therapeutic agents

In the study presented here, a new series of 2-furyl(4-{4-[(substituted)sulfonyl]benzyl}-1-piperazinyl)methanone derivatives was targeted. The synthesis was initiated by the treatment of different secondary amines (1a-h) with 4-bromomethylbenzenesulfonyl chloride (2) to obtain various 1-{[4-(bromome...

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Bibliographic Details
Main Authors:	Abbasi, M.A (Author), Ahmad, I. (Author), Ashraf, M. (Author), Aziz-ur-Rehman (Author), Fatima, H. (Author), Hussain, G. (Author), Khan, F.A (Author), Lodhi, M.A (Author), Malik, R. (Author), Qurat-ul-Ain (Author), Shah, S.A.A (Author), Shahid, M. (Author), Siddiqui, S.Z (Author)
Format:	Article
Language:	English
Published:	Faculdade de Ciencias Farmaceuticas (Biblioteca) 2017
Subjects:	[4 [4 [(3,5 dimethyl 4 morpholinyl)sulfonyl]benzyl] 1 piperazinyl](2 furyl)methanone 2 furyl [4 [4 (1 piperidinylsulfonyl)benzyl] 1 piperazinyl]methanone 2 furyl [4 [4 (4 morpholinylsulfonyl)benzyl] 1 piperazinyl]methanone 2 furyl [4 [4 [(2 methyl 1 piperidinyl)sulfonyl]benzyl] 1 piperazinyl]methanone 2 furyl [4 [4 [(2,6 dimethyl 1 piperidinyl)sulfonyl]benzyl] 1 piperazinyl] 2 methanone 2 furyl [4 [4 [(3 methyl 1 piperidinyl)sulfonyl]benzyl] 1 piperazinyl]methanone 2 furyl [4 [4 [(3,5 dimethyl 1 piperidinyl)sulfonyl]benzyl] 1 piperazinyl]methanone 2 furyl [4 [4 [(4 methyl 1 piperidinyl)sulfonyl]benzyl] 1 piperazinyl]methanone acetylcholinesterase antibacterial activity antiinfective agent Article Bacillus subtilis cholinesterase controlled study cytotoxicity test drug determination drug structure drug synthesis electrospray mass spectrometry enzyme activity Escherichia coli IC50 infrared spectroscopy methanone derivative molecular docking nonhuman physostigmine Piperazine derivatives/ hemolytic activity Piperazine derivatives/antimicrobial activity Piperazine derivatives/Cholinesterase assays Piperazine derivatives/in silico proton nuclear magnetic resonance Salmonella enterica serovar Typhi Staphylococcus aureus unclassified drug
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Synthesis and in silico study of 2-furyl(4-{4-[(substituted)sulfonyl]benzyl}-1-piperazinyl)methanone derivatives as suitable therapeutic agents

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