Biological activity of synthesized 5-{1-[(4-chlorophenyl)sulfonyl]piperidin-4-yl}-2-mercapto-1,3,4-oxadiazole derivatives demonstrated by in silico and bsa binding studies

We synthesized a series of compounds bearing pharmacologically important 1,3,4-oxadiazole and piperidine moieties. Spectral data analysis by1H-NMR,13C-NMR, IR and EI-MS was used to elucidate the structures of the synthesized molecules. Docking studies explained the different types of interaction of...

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Main Authors:	Abbasi, M.A (Author), Ashraf, M. (Author), Chohan, T.A (Author), Hamid, S. (Author), Iqbal, A. (Author), Iqbal, J. (Author), Khalid, H. (Author), Laulloo, S.J (Author), Rasool, S. (Author), Shah, S.A.A (Author), Siddiqui, S.Z (Author), Ur-Rehman, A. (Author)
Format:	Article
Language:	English
Published:	Faculdade de Ciencias Farmaceuticas (Biblioteca), 2020
Subjects:	1 [(4 chlorophenyl)sulfonyl]piperidin 4 carbohydrazide 1,3,4-Oxadiazole 5 {1 [(4 chlorophenyl)sulfonyl]piperidin 4 yl} 2 (allylthio) 1,3,4 oxadiazole 5 {1 [(4 chlorophenyl)sulfonyl]piperidin 4 yl} 2 (benzylthio) 1,3,4 oxadiazole 5 {1 [(4 chlorophenyl)sulfonyl]piperidin 4 yl} 2 (ethylthio) 1,3,4 oxadiazole 5 {1 [(4 chlorophenyl)sulfonyl]piperidin 4 yl} 2 [(1 butyl)thio] 1,3,4 oxadiazole 5 {1 [(4 chlorophenyl)sulfonyl]piperidin 4 yl} 2 [(1 heptyl)thio] 1,3,4 oxadiazole 5 {1 [(4 chlorophenyl)sulfonyl]piperidin 4 yl} 2 [(1 octyl)thio] 1,3,4 oxadiazole 5 {1 [(4 chlorophenyl)sulfonyl]piperidin 4 yl} 2 [(1 pentyl)thio] 1,3,4 oxadiazole 5 {1 [(4 chlorophenyl)sulfonyl]piperidin 4 yl} 2 [(1 propyl)thio] 1,3,4 oxadiazole 5 {1 [(4 chlorophenyl)sulfonyl]piperidin 4 yl} 2 [(1,3 dioxalan 2 ylmethyl)thio] 1,3,4 oxadiazole 5 {1 [(4 chlorophenyl)sulfonyl]piperidin 4 yl} 2 [(2 bromobenzyl)thio] 1,3,4 oxadiazole 5 {1 [(4 chlorophenyl)sulfonyl]piperidin 4 yl} 2 [(2 bromoethyl)thio] 1,3,4 oxadiazole 5 {1 [(4 chlorophenyl)sulfonyl]piperidin 4 yl} 2 [(2 butyl)thio] 1,3,4 oxadiazole 5 {1 [(4 chlorophenyl)sulfonyl]piperidin 4 yl} 2 [(2 chlorobenzyl)thio] 1,3,4 oxadiazole 5 {1 [(4 chlorophenyl)sulfonyl]piperidin 4 yl} 2 [(2 chloroethyl)thio] 1,3,4 oxadiazole 5 {1 [(4 chlorophenyl)sulfonyl]piperidin 4 yl} 2 [(2 iodoethyl)thio] 1,3,4 oxadiazole 5 {1 [(4 chlorophenyl)sulfonyl]piperidin 4 yl} 2 [(2 methylbenzyl)thio] 1,3,4 oxadiazole 5 {1 [(4 chlorophenyl)sulfonyl]piperidin 4 yl} 2 [(2 pentyl)thio] 1,3,4 oxadiazole 5 {1 [(4 chlorophenyl)sulfonyl]piperidin 4 yl} 2 [(2 phenylethyl)thio] 1,3,4 oxadiazole 5 {1 [(4 chlorophenyl)sulfonyl]piperidin 4 yl} 2 [(2 propyl)thio] 1,3,4 oxadiazole 5 {1 [(4 chlorophenyl)sulfonyl]piperidin 4 yl} 2 [(3 chlorobenzyl)thio] 1,3,4 oxadiazole 5 {1 [(4 chlorophenyl)sulfonyl]piperidin 4 yl} 2 [(3 nitrobenzyl)thio] 1,3,4 oxadiazole 5 {1 [(4 chlorophenyl)sulfonyl]piperidin 4 yl} 2 [(3 phenylpropyl)thio] 1,3,4 oxadiazole 5 {1 [(4 chlorophenyl)sulfonyl]piperidin 4 yl} 2 [(4 bromobenzyl)thio] 1,3,4 oxadiazole 5 {1 [(4 chlorophenyl)sulfonyl]piperidin 4 yl} 2 [(4 chlorobenzyl)thio] 1,3,4 oxadiazole 5 {1 [(4 chlorophenyl)sulfonyl]piperidin 4 yl} 2 [(4 fluorobenzyl)thio] 1,3,4 oxadiazole 5 {1 [(4 chlorophenyl)sulfonyl]piperidin 4 yl} 2 [(4 nitrobenzyl)thio] 1,3,4 oxadiazole 5 {1 [(4 chlorophenyl)sulfonyl]piperidin 4 yl} 2 [(alkyl/aralkyl)thio] 1,3,4 oxadiazole 5 {1 [(4 chlorophenyl)sulfonyl]piperidin 4 yl} 2 mercapto 1,3,4 oxadiazole 5 {1 [(4 chlorophenyl)sulfonyl]piperidin 4 yl} 2 mercapto 1,3,4 oxadiazole derivative acetylcholinesterase Acetylcholinesterase (AChE) inhibition antibacterial activity Antibacterial activity antiinfective agent Article Bacillus subtilis bacterial strain binding affinity binding site biological activity bovine serum albumin carbon nuclear magnetic resonance chemical structure drug efficacy drug synthesis elemental analysis enzyme activity enzyme inhibition ethyl 1 [(4 chlorophenyl) sulfonyl] piperidin 4 carboxylate hydrogen bond IC50 infrared spectroscopy minimum inhibitory concentration molecular docking molecular dynamics nonhuman oxadiazole derivative Piperidine proton nuclear magnetic resonance Salmonella enterica serovar Typhi Schiff base structure activity relation Sulfonamide thin layer chromatography unclassified drug urease Urease inhibition
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Biological activity of synthesized 5-{1-[(4-chlorophenyl)sulfonyl]piperidin-4-yl}-2-mercapto-1,3,4-oxadiazole derivatives demonstrated by in silico and bsa binding studies

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