Neuroprotective effect of poly(lactic-co-glycolic acid) nanoparticle-bound brain-derived neurotrophic factor in a permanent middle cerebral artery occlusion model of ischemia in rats

Neuroprotective effect of poly(lactic-co-glycolic acid) nanoparticle-bound brain-derived neurotrophic factor in a permanent middle cerebral artery occlusion model of ischemia in rats

Poly (lactide-co-glycolide) (PLGA) nanoparticles (NPs) are biodegradable carriers that participate in the transport of neuroprotective drugs across the blood brain barrier (BBB). Targeted brain-derived neurotrophic factor (BDNF) delivery across the BBB could provide neuroprotection in brain injury....

Full description

Bibliographic Details
Main Authors: Alyautdin, R. (Author), Iezhitsa, I. (Author), Ismail, N.M (Author), Kamarudin, S.N (Author), Tripathy, M. (Author)
Format: Article
Language:English
Published: Nencki Institute of Experimental Biology, 2020
Subjects:
administration and dosage
animal
Animals
BDNF
blood
brain derived neurotrophic factor
Brain infarct volume
Brain-Derived Neurotrophic Factor
cerebral artery disease
complication
drug carrier
Drug Carriers
enolase
Grid-walking test
Infarction, Middle Cerebral Artery
Ischemia
male
Male
nanoparticle
Nanoparticles
Neurological deficits
Neuron specific enolase
Neuroprotection
neuroprotective agent
Neuroprotective Agents
paresis
Paresis
pathology
Phosphopyruvate Hydratase
Polylactic Acid-Polyglycolic Acid Copolymer
protein S100B
Random Allocation
randomization
rat
Rats
Rats, Sprague-Dawley
Rotarod Performance Test
rotarod test
Rotarod test
S100 Calcium Binding Protein beta Subunit
S100β protein
severity of illness index
Severity of Illness Index
Sprague Dawley rat
Online Access:View Fulltext in Publisher
View in Scopus

Internet

View Fulltext in Publisher
View in Scopus

Similar Items