3,5-Dibenzyloxy-4'-hydroxystilbene induces early caspase-9 activation during apoptosis in human K562 chronic myelogenous leukemia cells

3,5-Dibenzyloxy-4'-hydroxystilbene induces early caspase-9 activation during apoptosis in human K562 chronic myelogenous leukemia cells

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A series of 22 stilbene derivatives based on resveratrol were synthesized incorporating acetoxy-, benzyloxy-, carboxy-, chloro-, hydroxy-and methoxy functional groups. We examined the cytotoxicity of these 22 stilbenes in human K562 chronic myelogenous leukemia cells. Only four compounds were cytoto...

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Bibliographic Details
Main Authors: Bunyamin, I. (Author), Chan, K.M (Author), Inayat-Hussain, S.H (Author), Kadir, S.A.I.A.S.A (Author), Majeed, A.B.A (Author), Myatt, G. (Author), Rajab, N.F (Author), Roslie, H. (Author), Thomas, N.F (Author), Velu, S.S (Author), Weber, J.-F.F (Author)
Format: Article
Language:English
Subjects:
3' acetoxy 4 chlorostilbene
3,5 dibezyloxy 4' hydroxystilbene
4' hydroxy 3 methoxystilbene
4' hydroxy 3,5 dimethoxystilbene
antineoplastic activity
antineoplastic agent
apoptosis
Apoptosis
article
caspase 3
caspase 9
Caspase 9
Caspase-3
Caspase-9
Cell Survival
chronic myeloid leukemia
drug synthesis
human
human cell
Humans
K562 cells
K562 Cells
leukemia cell
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Membrane Potential, Mitochondrial
Mitochondria
mitochondrial membrane potential
nonhuman
stilbene derivative
Stilbene derivatives
Stilbenes
structure activity relation
Structure-Activity Relationship
unclassified drug
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