3,5-Dibenzyloxy-4'-hydroxystilbene induces early caspase-9 activation during apoptosis in human K562 chronic myelogenous leukemia cells

A series of 22 stilbene derivatives based on resveratrol were synthesized incorporating acetoxy-, benzyloxy-, carboxy-, chloro-, hydroxy-and methoxy functional groups. We examined the cytotoxicity of these 22 stilbenes in human K562 chronic myelogenous leukemia cells. Only four compounds were cytoto...

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Main Authors:	Bunyamin, I. (Author), Chan, K.M (Author), Inayat-Hussain, S.H (Author), Kadir, S.A.I.A.S.A (Author), Majeed, A.B.A (Author), Myatt, G. (Author), Rajab, N.F (Author), Roslie, H. (Author), Thomas, N.F (Author), Velu, S.S (Author), Weber, J.-F.F (Author)
Format:	Article
Language:	English
Subjects:	3' acetoxy 4 chlorostilbene 3,5 dibezyloxy 4' hydroxystilbene 4' hydroxy 3 methoxystilbene 4' hydroxy 3,5 dimethoxystilbene antineoplastic activity antineoplastic agent apoptosis Apoptosis article caspase 3 caspase 9 Caspase 9 Caspase-3 Caspase-9 Cell Survival chronic myeloid leukemia drug synthesis human human cell Humans K562 cells K562 Cells leukemia cell Leukemia, Myelogenous, Chronic, BCR-ABL Positive Membrane Potential, Mitochondrial Mitochondria mitochondrial membrane potential nonhuman stilbene derivative Stilbene derivatives Stilbenes structure activity relation Structure-Activity Relationship unclassified drug
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3,5-Dibenzyloxy-4 '-hydroxystilbene induces early caspase-9 activation during apoptosis in human K562 chronic myelogenous leukemia cells

by Abd Kadir, SAAS, Bunyamin, I, Chan, KM, Inayat-Hussain, SH, Majeed, ABA, Myatt, G, Rajab, NF, Roslie, H, Thomas, NF, Velu, SS, Weber, JFF

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3,5-Dibenzyloxy-4'-hydroxystilbene induces early caspase-9 activation during apoptosis in human K562 chronic myelogenous leukemia cells

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