Smart nanocrystals of artemether: Fabrication, characterization, and comparative in vitro and in vivo antimalarial evaluation

Artemether (ARTM) is a very effective antimalarial drug with poor solubility and consequently low bioavailability. Smart nanocrystals of ARTM with particle size of 161±1.5 nm and polydispersity index of 0.172±0.01 were produced in <1 hour using a wet milling technology, Dena® DM-100. The crystall...

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Bibliographic Details
Main Authors:	AabdEel-Salam, N.M (Author), Aassi, K.H (Author), de Matas, M. (Author), Hhussain, Z. (Author), Iisreb, M. (Author), Khan, S. (Author), Minhas, M.U (Author), Shah, S.M.H (Author), Shah, S.M.M (Author), Ullah, F. (Author)
Format:	Article
Language:	English
Published:	Dove Medical Press Ltd. 2016
Subjects:	acute toxicity analysis of variance Analysis of Variance animal animal experiment animal model Animals antimalarial activity Antimalarial activity antimalarial agent Antimalarials artemether Artemether artemisinin derivative Artemisinins Article bioavailability Biological Availability biotechnology chemistry Chemistry, Pharmaceutical comparative study controlled study drug effects Drug Liberation drug release drug screening drug stability Drug Stability drug synthesis female hydroxypropylmethylcellulose Hypromellose Derivatives IC50 In vitro dissolution in vitro study in vivo study LD50 Lethal Dose 50 malaria falciparum Malaria, Vivax male Male medical device medicinal chemistry Mice Milling mouse nanocrystal nanoparticle Nanoparticles Nanosuspension nonhuman parasitemia parasitology particle size Particle Size Plasmodium falciparum Plasmodium vivax Plasmodium vivax malaria povidone Povidone Smart nanocrystals solubility Solubility suspension tablet tablet formulation Tablets
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Smart nanocrystals of artemether: Fabrication, characterization, and comparative in vitro and in vivo antimalarial evaluation

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