Aceclofenac nanocrystals with enhanced in vitro, in vivo performance: Formulation optimization, characterization, analgesic and acute toxicity studies

This study was aimed to enhance the dissolution rate, oral bioavailability and analgesic potential of the aceclofenac (AC) in the form of nanosuspension using cost-effective simple precipitation–ultrasonication approach. The nanocrystals were produced using the optimum conditions investigated for AC...

Full description

Bibliographic Details
Main Authors:	Hussain, Z. (Author), Ibrahim, K. (Author), Khan, M.A (Author), Khan, S. (Author), Rahim, H. (Author), Sadiq, A. (Author), Shah, S.M.H (Author), Shahat, A.A (Author), Ullah, R. (Author)
Format:	Article
Language:	English
Published:	Dove Medical Press Ltd. 2017
Subjects:	aceclofenac Aceclofenac nanocrystals albino rabbit analgesic activity analogs and derivatives animal animal experiment Animals Anti-Inflammatory Agents, Non-Steroidal antinociception Area Under Curve area under the curve Article bioavailability Biological Availability chemistry Chemistry, Pharmaceutical comparative study controlled study diclofenac Diclofenac differential scanning calorimetry dispersity Dissolution rate dodecyl sulfate sodium dose response Dose-Response Relationship, Drug drug absorption drug bioavailability drug screening drug solubility drug stability drug structure excipient Excipients hydroxypropylmethylcellulose in vitro study In vivo studies in vivo study Leporidae male Male maximum plasma concentration medicinal chemistry Mice mouse nanocrystal nanoparticle Nanoparticles nonhuman nonsteroid antiinflammatory agent particle size Particle Size povidone derivative Precipitation–ultrasonication procedures process optimization Rabbits scanning electron microscopy solubility Solubility structure analysis tablet formulation toxicity testing Toxicity Tests, Acute transmission electron microscopy venlafaxine X ray diffraction zeta potential
Online Access:	View Fulltext in Publisher View in Scopus

Internet

View Fulltext in Publisher
View in Scopus

Aceclofenac nanocrystals with enhanced in vitro, in vivo performance: Formulation optimization, characterization, analgesic and acute toxicity studies

Internet

Similar Items