Tocotrienol-rich fraction modulate the phosphoinositide 3-kinases/Akt signaling pathway genes and prevent oxidative stress in nicotine-induced pre-implantation embryos

Tocotrienol-rich fraction modulate the phosphoinositide 3-kinases/Akt signaling pathway genes and prevent oxidative stress in nicotine-induced pre-implantation embryos

Objective: This study aimed to determine the effects of the tocotrienol-rich fraction (TRF) on the regulations of phosphoinositide 3-kinases (PI3K)/Akt pathways related genes in preimplantation embryos induced by nicotine (Nic). Methods: Twenty-four female BALB/c mice were divided into four groups w...

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Bibliographic Details
Main Authors: Ab-Rahim, S. (Author), Kamsani, N.H (Author), Kamsani, Y.S (Author), Khan, N.A.M.N (Author), Rajikin, M.H (Author)
Format: Article
Language:English
Published: Innovare Academics Sciences Pvt. Ltd 2019
Subjects:
alpha tocotrienol
animal cell
animal experiment
animal model
animal tissue
Article
blastomere
catalase
controlled study
down regulation
embryo
female
gene
gene expression
glutathione peroxidase
glycogen synthase kinase 3beta
malonaldehyde
mitogen activated protein kinase 1
mouse
nicotine
Nicotine
nonhuman
oxidative stress
phosphatidylinositol 3 kinase
phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase
Pi3K/Akt signaling
preimplantation embryo
Preimplantation embryo
protein kinase B
superoxide dismutase
Tocotrienol-rich fraction
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