Heterologous production of ascofuranone and ilicicolin A in Aspergillus sojae

Heterologous production of ascofuranone and ilicicolin A in Aspergillus sojae

Ascofuranone and its precursor, ilicicolin A, are secondary metabolites with various pharmacological activities that are produced by Acremonium egyptiacum. In particular, ascofuranone strongly inhibits trypanosome alternative oxidase and represents a potential drug candidate against African trypanos...

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Bibliographic Details
Main Authors: Araki, Y. (Author), Gomi, K. (Author), Hara, S. (Author), Ito, K. (Author), Kita, K. (Author), Sakaue, R. (Author), Sato, A. (Author), Shinohara, Y. (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
ascofuranone
Aspergillus sojae
filamentous fungi
heterologous expression
ilicicolin A
multi-copy integration
secondary metabolites
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