Bromodomain Inhibition Reveals FGF15/19 As a Target of Epigenetic Regulation and Metabolic Control

Bromodomain Inhibition Reveals FGF15/19 As a Target of Epigenetic Regulation and Metabolic Control

Epigenetic regulation is an important factor in glucose metabolism, but underlying mechanisms remain largely unknown. Here we investigated epigenetic control of systemic metabolism by bromodomain-containing proteins (Brds), which are transcriptional regulators binding to acetylated histone, in both...

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Main Authors: Aguayo-Mazzucato, C. (Author), Alonso-Curbelo, D. (Author), Carapeto, P. (Author), Chimene-Weiss, J. (Author), Desmond, J. (Author), Efthymiou, V. (Author), Gerszten, R.E (Author), Goodyear, L. (Author), Isganaitis, E. (Author), Kozuka, C. (Author), Kusuyama, J. (Author), Mulla, C. (Author), Osataphan, S. (Author), Patti, M.-E (Author), Qi, J. (Author), Sales, V.M (Author), Sandoval, D. (Author), Sanechika, S. (Author), Shi, X. (Author), Teixeira, S.D (Author), Wu, L. (Author), Yuchi, Y. (Author), Zhou, L. (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
animal
Animals
Epigenesis, Genetic
fibroblast growth factor
Fibroblast Growth Factors
genetic epigenesis
genetics
glucose
Glucose
hyperglycemia
Hyperglycemia
metabolism
Mice
mouse
nuclear protein
Nuclear Proteins
transcription factor
Transcription Factors
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