Alteration of the Individual Metabolic Network of the Brain Based on Jensen-Shannon Divergence Similarity Estimation in Elderly Patients With Type 2 Diabetes Mellitus

The aim of this study was to investigate the interactive effect between aging and type 2 diabetes mellitus (T2DM) on brain glucose metabolism, individual metabolic connectivity, and network properties. Using a 2 × 2 factorial design, 83 patients with T2DM (40 elderly and 43 middle-aged) and 69 sex-m...

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Main Authors: Hua, X.-Y (Author), Li, S.-S (Author), Li, Y.-L (Author), Ma, J. (Author), Shan, C.-L (Author), Wei, D. (Author), Wu, J.-J (Author), Xu, J.-G (Author), Xue, X. (Author), Zheng, M.-X (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
Online Access:View Fulltext in Publisher
LEADER 03222nam a2200481Ia 4500
001 10.2337-db21-0600
008 220510s2022 CNT 000 0 und d
020 |a 1939327X (ISSN) 
245 1 0 |a Alteration of the Individual Metabolic Network of the Brain Based on Jensen-Shannon Divergence Similarity Estimation in Elderly Patients With Type 2 Diabetes Mellitus 
260 0 |b NLM (Medline)  |c 2022 
856 |z View Fulltext in Publisher  |u https://doi.org/10.2337/db21-0600 
520 3 |a The aim of this study was to investigate the interactive effect between aging and type 2 diabetes mellitus (T2DM) on brain glucose metabolism, individual metabolic connectivity, and network properties. Using a 2 × 2 factorial design, 83 patients with T2DM (40 elderly and 43 middle-aged) and 69 sex-matched healthy control subjects (HCs) (34 elderly and 35 middle-aged) underwent 18F-fluorodeoxyglucose positron emission tomography/magnetic resonance scanning. Jensen-Shannon divergence was applied to construct individual metabolic connectivity and networks. The topological properties of the networks were quantified using graph theoretical analysis. The general linear model was used to mainly estimate the interaction effect between aging and T2DM on glucose metabolism, metabolic connectivity, and network. There was an interaction effect between aging and T2DM on glucose metabolism, metabolic connectivity, and regional metabolic network properties (all P < 0.05). The post hoc analyses showed that compared with elderly HCs and middle-aged patients with T2DM, elderly patients with T2DM had decreased glucose metabolism, increased metabolic connectivity, and regional metabolic network properties in cognition-related brain regions (all P < 0.05). Age and fasting plasma glucose had negative correlations with glucose metabolism and positive correlations with metabolic connectivity. Elderly patients with T2DM had glucose hypometabolism, strengthened functional integration, and increased efficiency of information communication mainly located in cognition-related brain regions. Metabolic connectivity pattern changes might be compensatory changes for glucose hypometabolism. © 2022 by the American Diabetes Association. 
650 0 4 |a aged 
650 0 4 |a Aged 
650 0 4 |a brain 
650 0 4 |a Brain 
650 0 4 |a Diabetes Mellitus, Type 2 
650 0 4 |a fluorodeoxyglucose f 18 
650 0 4 |a Fluorodeoxyglucose F18 
650 0 4 |a glucose 
650 0 4 |a Glucose 
650 0 4 |a human 
650 0 4 |a Humans 
650 0 4 |a Magnetic Resonance Imaging 
650 0 4 |a Metabolic Networks and Pathways 
650 0 4 |a metabolism 
650 0 4 |a middle aged 
650 0 4 |a Middle Aged 
650 0 4 |a non insulin dependent diabetes mellitus 
650 0 4 |a nuclear magnetic resonance imaging 
650 0 4 |a positron emission tomography 
650 0 4 |a Positron-Emission Tomography 
700 1 |a Hua, X.-Y.  |e author 
700 1 |a Li, S.-S.  |e author 
700 1 |a Li, Y.-L.  |e author 
700 1 |a Ma, J.  |e author 
700 1 |a Shan, C.-L.  |e author 
700 1 |a Wei, D.  |e author 
700 1 |a Wu, J.-J.  |e author 
700 1 |a Xu, J.-G.  |e author 
700 1 |a Xue, X.  |e author 
700 1 |a Zheng, M.-X.  |e author 
773 |t Diabetes