Restoration of Autophagic Flux Improves Endothelial Function in Diabetes Through Lowering Mitochondrial ROS-Mediated eNOS Monomerization

Restoration of Autophagic Flux Improves Endothelial Function in Diabetes Through Lowering Mitochondrial ROS-Mediated eNOS Monomerization

Endothelial nitric oxide synthase (eNOS) monomerization and uncoupling play crucial roles in mediating vascular dysfunction in diabetes, although the underlying mechanisms are still incompletely understood. Increasing evidence indicates that autophagic dysregulation is involved in the pathogenesis o...

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Bibliographic Details
Main Authors: Chen, Q. (Author), Gou, L. (Author), He, L. (Author), Huang, Y. (Author), Kang, L. (Author), Ko, H. (Author), Lau, C.W (Author), Liu, J. (Author), Liu, L. (Author), Luo, J.-Y (Author), Mok, V.C.T (Author), Qu, D. (Author), Song, W. (Author), Tian, X.Y (Author), Wang, L. (Author), Zhang, C.-L (Author), Zhao, L. (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
animal
Animals
autophagy
Autophagy
C57BL mouse
Diabetes Mellitus, Experimental
Endothelial Cells
endothelial nitric oxide synthase
endothelium cell
Endothelium, Vascular
experimental diabetes mellitus
genetics
mammal
Mammals
metabolism
Mice
Mice, Inbred C57BL
mouse
Nitric Oxide Synthase Type III
reactive oxygen metabolite
Reactive Oxygen Species
vascular endothelium
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