Mitofusins Mfn1 and Mfn2 Are Required to Preserve Glucose- but Not Incretin-Stimulated β-Cell Connectivity and Insulin Secretion

Mitofusins Mfn1 and Mfn2 Are Required to Preserve Glucose- but Not Incretin-Stimulated β-Cell Connectivity and Insulin Secretion

Mitochondrial glucose metabolism is essential for stimulated insulin release from pancreatic β-cells. Whether mitofusin gene expression, and hence, mitochondrial network integrity, is important for glucose or incretin signaling has not previously been explored. Here, we generated mice with β-cell-se...

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Main Authors: Akalestou, E. (Author), Ali, Y. (Author), Alsabeeh, N. (Author), Chabosseau, P. (Author), Cruciani-Guglielmacci, C. (Author), Georgiadou, E. (Author), Gu, G. (Author), Ibberson, M. (Author), Jones, B. (Author), Leclerc, I. (Author), Legido-Quigley, C. (Author), Linnemann, A.K (Author), Lopez-Noriega, L. (Author), Magnan, C. (Author), Martinez, M. (Author), Muralidharan, C. (Author), Rodriguez, T.A (Author), Rutter, G.A (Author), Soleimanpour, S.A (Author), Stylianides, T. (Author), Tomas, A. (Author), Wern, F.Y.S (Author), Wretlind, A. (Author), Xu, Y. (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
animal
Animals
genetics
glucose
Glucose
GTP Phosphohydrolases
guanine nucleotide exchange factor
Guanine Nucleotide Exchange Factors
guanosine triphosphatase
incretin
Incretins
insulin
Insulin
insulin release
Insulin Secretion
Insulin-Secreting Cells
knockout mouse
metabolism
Mfn1 protein, mouse
Mfn2 protein, mouse
Mice
Mice, Knockout
mouse
pancreas islet beta cell
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