Bioassay-guided isolation of ochrolifuanine: A bisindole alkaloid of Dyera costulata active on Trypanosoma brucei brucei

Bioassay-guided isolation of ochrolifuanine: A bisindole alkaloid of Dyera costulata active on Trypanosoma brucei brucei

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Dyera costulata, locally known as jelutong, have shown promising in vitro inhibitory activity against Trypanosoma brucei brucei strain BS221. The methanolic leaf extract, evaluated using Alamar Blue Assay, showed strong antitrypanosomal activity (IC50 0.58 ± 0.01 µg mL-1) and high selectivity index...

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Bibliographic Details
Main Authors: Getha, K. (Author), Lili-Sahira, H. (Author), Mohd-Hafidz-Hadi, A. (Author), Mohd-Ilham, A. (Author), Muhd-Haffiz, J. (Author), Muhd-Syamil, A. (Author), Norhayati, I. (Author), Nurhayati, Z.A (Author)
Format: Article
Language:English
Published: Forest Research Institute Malaysia 2018
Subjects:
alkaloid
Alkaloids
antimicrobial activity
Anti-microbial activity
Anti-trypanosomal activities
Antitrypanosomal activity
Apocynaceae
bioactivity
Bioactivity
bioassay
Bioassay guided fractionations
Biological Tests
Dyera
Dyera costulata
Essential oils
Fractionation
Inhibitory activity
isotopic fractionation
leaf
Leaves
Metabolites
Nuclear magnetic resonance spectroscopy
plant extract
Plants (botany)
protist
Protozoa
Selectivity
Selectivity index
Selectivity index (SI)
spectral analysis
Spectrum analysis
Total alkaloid extract
Trypanosoma brucei
Trypanosoma brucei brucei
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