Mitigation of radiation-induced lung injury by genistein and EUK-207

Mitigation of radiation-induced lung injury by genistein and EUK-207

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Purpose: We examined the effects of genistein and/or Eukarion (EUK)-207 on radiation-induced lung damage and investigated whether treatment for 0-14 weeks (wks) post-irradiation (PI) would mitigate late lung injury. Materials and methods: The lungs of female Sprague-Dawley (SD) rats were irradiated...

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Bibliographic Details
Main Authors: Calveley, V. (Author), Doctrow, S.R (Author), Hill, R.P (Author), Jelveh, S. (Author), Mahmood, J. (Author), Zaidi, A. (Author)
Format: Article
Language:English
Subjects:
8 hydroxydeoxyguanosine
animal experiment
Animalia
Animals
article
breathing rate
controlled study
DNA damage
EUK-207
female
Female
genistein
Genistein
hydroxyproline
immunohistochemistry
interleukin 1alpha
interleukin 1beta
interleukin 6
lung fibrosis
lung injury
macrophage activation
micronucleus
nonhuman
Organometallic Compounds
pneumonia
priority journal
protein expression
radiation
radiation exposure
Radiation Pneumonitis
Radiation-Protective Agents
rat
rat lung
Rats
Rats, Sprague-Dawley
Rattus
Respiratory Mechanics
ROS
transforming growth factor beta1
Treatment Outcome
tumor necrosis factor alpha
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