Identification of Recombinant Chimpanzee Adenovirus C68 Degradation Products Detected by AEX-HPLC

Identification of Recombinant Chimpanzee Adenovirus C68 Degradation Products Detected by AEX-HPLC

Physicochemical tests represent important tools for the analytical control strategy of biotherapeutics. For adenoviral modalities, anion-exchange high performance liquid chromatography (AEX-HPLC) represents an important methodology, as it is able to simultaneously provide information on viral partic...

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Bibliographic Details
Main Authors: Binder, J.J (Author), Friese, O. (Author), Mullins, E.K (Author), Powers, T.W (Author), Runnels, H.A (Author), Thompson, L.C (Author), Zhang, K. (Author)
Format: Article
Language:English
Published: Frontiers Media S.A. 2022
Subjects:
adenovirus
Adenovirus
AEX-HPLC
Amino acids
Anion exchange
Anion-exchange high performance liquid chromatography
deamidation
Deamidation
Degradation
hexon
Hexon
High performance liquid chromatography
High-performance liquid chromatography
kinetics
mass spectometry
Mass spectometry
Mass spectrometry
non-human primate
Non-human primate
Particles concentration
Physico-chemical test
Surface charge
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