Identification of Recombinant Chimpanzee Adenovirus C68 Degradation Products Detected by AEX-HPLC

Identification of Recombinant Chimpanzee Adenovirus C68 Degradation Products Detected by AEX-HPLC

Physicochemical tests represent important tools for the analytical control strategy of biotherapeutics. For adenoviral modalities, anion-exchange high performance liquid chromatography (AEX-HPLC) represents an important methodology, as it is able to simultaneously provide information on viral partic...

Full description

Bibliographic Details
Main Authors:	Binder, J.J (Author), Friese, O. (Author), Mullins, E.K (Author), Powers, T.W (Author), Runnels, H.A (Author), Thompson, L.C (Author), Zhang, K. (Author)
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022
Subjects:	adenovirus Adenovirus AEX-HPLC Amino acids Anion exchange Anion-exchange high performance liquid chromatography deamidation Deamidation Degradation hexon Hexon High performance liquid chromatography High-performance liquid chromatography kinetics mass spectometry Mass spectometry Mass spectrometry non-human primate Non-human primate Particles concentration Physico-chemical test Surface charge
Online Access:	View Fulltext in Publisher

Similar Items

Chromatographic and Spectroscopic Studies on Aquatic Fulvic Acid
by: Chang, David Juan-Yuan
Published: (1986)

Comparison of Liver Detargeting Strategies for Systemic Therapy with Oncolytic Adenovirus Serotype 5
by: Tien V. Nguyen, et al.
Published: (2017-08-01)

Quantification of Temozolomide in Nonhuman Primate Fluids by Isocratic Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry to Study Brain Tissue Penetration Following Intranasal or Intravenous Delivery
by: Cody J. Peer, et al.
Published: (2016-02-01)

ESI-MS fragmentation pathways of some 1,2,4-triazole-3-thiones, the intermediate compounds in the synthesis of active pharmaceutical ingredients
by: Borys O. Varynskyi, et al.
Published: (2020-03-01)

Epidemiological survey of avian adenovirus in China from 2015 to 2021 and the genetic variability of highly pathogenic Fadv-4 isolates
by: Chen, Z., et al.
Published: (2022)

Measurement of stable isotopic enrichment and concentration of long-chain fatty acyl-carnitines in tissue by HPLC-MS
by: Dayong Sun, et al.
Published: (2006-02-01)

Chemical characterization of the photodegradation products of midazolam complexes with randomly methylated-β-cyclodextrin by HPLC and LC-MS/MS
by: Agatonovic-Kustrin Snezana, et al.
Published: (2016-01-01)

Chemical characterization of the photodegradation products of midazolam complexes with randomly methylated-β-cyclodextrin by HPLC and LC-MS/MS
by: Agatonovic-Kustrin, S., et al.
Published: (2016)

Adenoviruses in Fecal Samples from Asymptomatic Rhesus Macaques, United States
by: Soumitra Roy, et al.
Published: (2012-07-01)

Comparison and optimization of chromatographic conditions for separation of cyclic dynorphin A analogues from linear byproducts
by: Leelasvatanakij, Leena
Published: (2013)

Molecular epidemiology of human Adenovirus among patients with Keratoconjunctivitis
by: Sazan Qadir Maulud
Published: (2019-06-01)

Small-size recombinant adenoviral hexon protein fragments for the production of virus-type specific antibodies
by: Martin Pacesa, et al.
Published: (2017-08-01)

PROFILING OF HORMONES IN PLANT TISSUES: HISTORY, MODERN APPROACHES, USE IN BIOTECHNOLOGY
by: І. V. Kosakivska, et al.
Published: (2020-08-01)

Mass-spectrometric fragmentation of sodium 2-(4-methyl-5-(thiophene-2-yl)-4H-1,2,4-triazole-3-ylthio)acetate
by: V. A. Salionov, et al.
Published: (2015-10-01)

Extramedullary hematopoiesis in case of hemoglobin E Beta-thalassemia: An unusual cause of paraplegia
by: Prita Pradhan, et al.
Published: (2019-01-01)

Profiling and quantification of aminophospholipids based on chemical derivatization coupled with HPLC-MS[S]
by: Hui-Fang Ma, et al.
Published: (2019-01-01)

COMPARAÇÃO DE MÉTODOS POR CROMATOGRAFIA LÍQUIDA NA DETERMINAÇÃO DE MULTIRRESÍDUOS DE AGROTÓXICOS EM MORANGOS
by: Daniele Oshita, et al.
Published: (2015-12-01)

Development of a Reverse-Phase High-Performance Liquid Chromatography and Liquid Chromatography Tandem Mass Spectrometry Methods for Quality Control of Daegunjoong-Tang
by: Chang-Seob Seo, et al.
Published: (2021-04-01)

Determination of steroid hormones in human hair as a retrospective biomarker with HPLC-MS/MS
by: Wei Gao, et al.
Published: (2012-09-01)

Rapid Isolation and Purification of Plasmid DNA Using High Performance Liquid Chromatography
by: Nam, Kiebang
Published: (1987)

HPLC Separation of All Aldopentoses and Aldohexoses on an Anion-Exchange Stationary Phase Prepared from Polystyrene-Based Copolymer and Diamine: The Effect of NaOH Eluent Concentration
by: Takako Masuda-Hanada, et al.
Published: (2011-07-01)

An evaluation of UPLC technology for the simultaneous analysis of actives in a multi-active drug
by: Bawjee, Janita
Published: (2011)

Screening
by: Dina A. Ghoraba, et al.
Published: (2014-01-01)

TOXICOLOGICAL DRUG SCREENING BY GC-MS VERSUS HPLC-DAD USING A COMMON EFFICIENT EXTRACTION PROCEDURE SCREENING TOXICOLOGIQUE DES MEDICAMENTS PAR HPLC-DAD ET GC-MS: PROTOCOLE D’EXTRACTION UNIQUE
by: SELOUA ELMRABEH, et al.
Published: (2015-05-01)

A review on biomarkers in clinical osteoporosis - Significance of hydroxyproline
by: Soumya Adugani, et al.
Published: (2021-01-01)

Method development and applications of capillary electrophoresis, liquid chromatography and mass spectrometry for the separation and determination of urinary prophyrins
by: Li, Jinhua
Published: (2009)

An improved LC-MS/MS procedure for brain prostanoid analysis using brain fixation with head-focused microwave irradiation and liquid-liquid extraction
by: Mikhail Y. Golovko, et al.
Published: (2008-04-01)

Determination of Colistin B in Chicken Muscle and Egg Using Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry
by: Harsh Kumar, et al.
Published: (2021-03-01)

Lipemia in the Plasma Sample Affects Fentanyl Measurements by Means of HPLC-MS<sup>2</sup> after Liquid-Liquid Extraction
by: Marta Tikhomirov, et al.
Published: (2021-07-01)

Determination of Diphenylamine in Gunshot Residue by HPLC-MS/MS
by: Hongcheng Mei, et al.
Published: (2016-01-01)

Analytical procedures for the determination of wattle polyphenols in wastewaters
by: Hendry, Antony John
Published: (1984)

Comprehensive Polyphenolic Profile of Plantago depressa using High-Speed Countercurrent Chromatography Off-line with High-Performance Liquid Chromatography–Diode Array Detector–Quadrupole Time-of-flight Tandem Mass Spectrometry
by: Jinju Xu, et al.
Published: (2019-11-01)

Progress in Adenoviral Capsid-Display Vaccines
by: Marija Vujadinovic, et al.
Published: (2018-07-01)

DEVELOPMENT AND VALIDATION OF A HPLC METHOD FOR DETERMINATION AND QUANTIFICATION OF RUBRAXANTHONE IN STEM BARK EXTRACT OF MANGOSTEEN
by: Meri Susanti, et al.
Published: (2014-10-01)

Effect of oligomer chain length and substituent configuration on the enantioselectivity of a maltooligosaccharide chiral stationary phrase for HPLC
by: Williams, Karen L
Published: (2009)

A study of some aspects of capillary electrophoresis in drug analysis
by: Vorarat, Suwanna
Published: (2000)

Application of high-performance liquid chromatography to the analysis, stability and pharmacokinetics of erythromycin
by: Stubbs, Christopher
Published: (1988)

Identification of Two Novel Linear Neutralizing Epitopes within the Hexon Protein of Canine Adenovirus Using Monoclonal Antibodies
by: Shujie Wang, et al.
Published: (2021-02-01)

Open-access metabolomics databases for natural product research: present capabilities and future potential
by: Sean R Johnson, et al.
Published: (2015-03-01)

Causes of unsatisfactory results of the use of mitomycin-C in endoscopic endonasal dacryocystorhinostomy
by: E.L. Atkova, et al.
Published: (2017-07-01)