Downregulation of miR-760 Causes Human Intervertebral Disc Degeneration by Targeting the MyD88/Nuclear Factor-Kappa B Signaling Pathway

Downregulation of miR-760 Causes Human Intervertebral Disc Degeneration by Targeting the MyD88/Nuclear Factor-Kappa B Signaling Pathway

Dysregulation of microRNAs (miRNAs) plays a critical role in the development of intervertebral disc degeneration (IDD). In this study, we present evidence from in vitro and in vivo research to elucidate the mechanism underlying the role of miR-760 in IDD. miRNA microarray and quantitative reverse tr...

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Bibliographic Details
Main Authors: Bao, J. (Author), Cui, X. (Author), Li, Y. (Author), Wang, K. (Author), Wu, X. (Author)
Format: Article
Language:English
Published: Frontiers Media S.A. 2022
Subjects:
Cell proliferation
Cell signaling
Down-regulation
intervertebral disc degeneration
Inter-vertebral disc degeneration
In-vitro
miR-760
Mir-760
Myd88
MyD88
NF-κb signaling pathway
NF-κB signaling pathway
Nuclear factors
Nucleus pulposi cell
Nucleus pulposus
nucleus pulposus cells
Patient treatment
Polymerase chain reaction
RNA
Signalling pathways
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