β-Cyclodextrin and Oligoarginine Peptide-Based Dendrimer-Entrapped Gold Nanoparticles for Improving Drug Delivery to the Inner Ear

β-Cyclodextrin and Oligoarginine Peptide-Based Dendrimer-Entrapped Gold Nanoparticles for Improving Drug Delivery to the Inner Ear

Here, we developed a safe and highly effective nanocarrier using β-cyclodextrin (β-CD) and oligoarginine peptide (Arg8)-modified dendrimer-entrapped gold nanoparticles (Au@CD-PAMAM-Arg8), with a diameter of 5 nm, for improved delivery of dexamethasone (Dex) to the inner ear. The properties and in vi...

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Bibliographic Details
Main Authors: Li, L. (Author), Li, P. (Author), Lin, X. (Author), Luo, J. (Author), Tan, J. (Author)
Format: Article
Language:English
Published: Frontiers Media S.A. 2022
Subjects:
Audition
Cells
Controlled drug delivery
Cyclodextrins
Cytology
Dendrimers
dexamethasone
Dexamethasones
drug delivery
Efficiency
Fiber optic sensors
Gold nanoparticle
Gold nanoparticles
Gold Nanoparticles
inner ear
Inner ear
In-vivo
Mammals
Metal nanoparticles
Nanocarriers
nerve fibers
Nerve fibers
Oligoarginine peptides
Outer hair cell
outer hair cells
Peptides
spiral ganglion
Spiral ganglion
Targeted drug delivery
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