Synaptic connectivity in medium spiny neurons of the nucleus accumbens: A sex-dependent mechanism underlying apathy in the HIV-1 transgenic rat

Synaptic connectivity in medium spiny neurons of the nucleus accumbens: A sex-dependent mechanism underlying apathy in the HIV-1 transgenic rat

Frontal-subcortical circuit dysfunction is commonly associated with apathy, a neuropsychiatric sequelae of human immunodeficiency virus type-1 (HIV-1). Behavioral and neurochemical indices of apathy in the nucleus accumbens (NAc), a key brain region involved in frontal-subcortical circuitry, are inf...

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Bibliographic Details
Main Authors: Booze, R.M (Author), Cook, A.K (Author), League, A.F (Author), Li, H. (Author), Mactutus, C.F (Author), McLaurin, K.A (Author)
Format: Article
Language:English
Published: Frontiers Media S.A. 2018
Subjects:
adrenergic transmission
animal cell
animal experiment
animal model
animal tissue
apathy
Apathy
Article
Biological sex
brain region
cell population
cell volume
cellular distribution
connectome
controlled study
dendritic spine
Diagnostic classification
Discriminant function analysis
Dopamine
female
functional connectivity
glutamic acid
HIV-1 transgenic rat
Human immunodeficiency virus 1
long term exposure
male
medium spiny neuron
Medium spiny neurons
nerve cell membrane
nonhuman
nucleus accumbens
rat
sex difference
sexual development
transgene
transgenic rat
viral protein
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