Latent Sex Differences in CaMKII-nNOS Signaling That Underlie Antidepressant-Like Effects of Yueju-Ganmaidazao Decoction in the Hippocampus

Latent Sex Differences in CaMKII-nNOS Signaling That Underlie Antidepressant-Like Effects of Yueju-Ganmaidazao Decoction in the Hippocampus

Previous studies have demonstrated that Yueju-Ganmaidazao (YG) decoction induces rapid antidepressant-like effects, and the antidepressant response is mostly dependent on the suppression of nitric oxide-cyclic guanosine monophosphate signaling in male mice. This study aimed to investigate the sex di...

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Bibliographic Details
Main Authors: Chen, Y. (Author), Ge, R. (Author), Han, J. (Author), Li, J. (Author), Li, Y. (Author), Liu, L. (Author), Qian, S. (Author), Sun, D. (Author), Sun, Y. (Author), Wang, W. (Author), Wu, H. (Author), Wu, Z. (Author), Xue, W. (Author), Yin, Y. (Author), Yu, X. (Author), Yu, Y. (Author)
Format: Article
Language:English
Published: Frontiers Media S.A. 2021
Subjects:
7 nitroindazole
adult
antidepressant activity
Article
Atractylodes lancea
calcium calmodulin dependent protein kinase II
CaMKII
chronic unpredictable stress
controlled study
CREB
Curabitur triticum
cyclic AMP responsive element binding protein
Cyperus rotundus
escitalopram
feeding
female
forced swim test
Fructus Ziziphus Jujuba
Gardenia jasminoides
Glycyrrhiza glabra root
hippocampus
immobility
Ligusticum sinense
lipopolysaccharide
male
Massa fermentata
mouse
n [2 [[n [3 (4 chlorophenyl) 2 propenyl] n methylamino]methyl]phenyl] n (2 hydroxyethyl) 4 methoxybenzenesulfonamide
neuronal nitric oxide synthase
neuroprotection
nNOS
nonhuman
open field test
phenotype
protein expression
protein synthesis regulation
sex difference
signal transduction
sucrose preference test
tail suspension test
unclassified drug
YG
yueju ganmaidazao
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