Chronic Isolation Stress Affects Central Neuroendocrine Signaling Leading to a Metabolically Active Microenvironment in a Mouse Model of Breast Cancer

Chronic Isolation Stress Affects Central Neuroendocrine Signaling Leading to a Metabolically Active Microenvironment in a Mouse Model of Breast Cancer

Social isolation is a powerful stressor capable of affecting brain plasticity and function. In the case of breast cancer, previous data indicate that stressful experiences may contribute to a worse prognosis, activating neuroendocrine and metabolism pathways, although the mechanisms underlying these...

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Bibliographic Details
Main Authors: Aricò, E. (Author), Berry, A. (Author), Capoccia, S. (Author), Cecchetti, S. (Author), Cirulli, F. (Author), Collacchi, B. (Author), D'Urso, M.T (Author), Ortona, E. (Author), Pontecorvi, G. (Author), Puglisi, R. (Author), Raggi, C. (Author), Sestili, P. (Author)
Format: Article
Language:English
Published: Frontiers Media S.A. 2021
Subjects:
adiponectin
age
agouti related protein
AgRP gene
animal behavior
animal experiment
animal model
Article
Bdnf gene
brain derived neurotrophic factor
breast cancer
brown adipose tissue
chronic stress
corticosterone
corticosterone blood level
depression
emotion
endocrine function
experimental reward addiction test
fat pad
female
forced swim test
gene expression
hedonism
HPA axis
hypothalamus
hypothalamus hypophysis adrenal system
immobilization stress
leptin
lipid metabolism
mammary gland
metabolic regulation
mood
mouse
mouse model
neuroendocrine signaling
neuropeptide Y
nonhuman
NpY gene
NPY/AgRP
protein expression
saccharin
saccharin preference test
serum and glucocorticoid regulated kinase 1
SgK1 gene
social isolation
social isolation stress
tumor metabolism
tumor microenvironment
weaning
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