Effects of Maternal Deprivation on the Prefrontal Cortex of Male Rats: Cellular, Neurochemical, and Behavioral Outcomes

Effects of Maternal Deprivation on the Prefrontal Cortex of Male Rats: Cellular, Neurochemical, and Behavioral Outcomes

Stressful events experienced during early life are associated with increased vulnerability of developing psychopathology in adulthood. In the present study, we exposed 9-day-old Wistar rats to 24 h maternal deprivation (MD) with the aim to investigate the impact of early life stress (ELS) on morphol...

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Bibliographic Details
Main Authors: Aksic, M. (Author), Aleksic, D. (Author), Djulejic, V. (Author), Kapor, S. (Author), Markovic, B. (Author), Poleksic, J. (Author), Radovic, M. (Author), Stamatakis, A. (Author), Stojkovic, T. (Author)
Format: Article
Language:English
Published: Frontiers Media S.A. 2021
Subjects:
adult
animal experiment
Article
BDNF
brain derived neurotrophic factor
brain region
cell activation
cell density
cholecystokinin
cingulate gyrus
cognitive flexibility
controlled study
early life stress
glutamate decarboxylase 67
immunohistochemistry
infralimbic cortex
interneuron
interneurons
lateral orbitofrontal cortex
male
maternal deprivation
medial orbitofrontal cortex
mental stress
microglia
nerve cell plasticity
newborn
nonhuman
parvalbumin
prefrontal cortex
prelimbic cortex
protein expression
rat
synaptic plasticity
T-maze test
upregulation
Western blotting
Wistar rat
young adult
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