Impact of Fluoxetine on Behavioral Invigoration of Appetitive and Aversively Motivated Responses: Interaction With Dopamine Depletion

Impact of Fluoxetine on Behavioral Invigoration of Appetitive and Aversively Motivated Responses: Interaction With Dopamine Depletion

Impaired behavioral activation and effort-related motivational dysfunctions like fatigue and anergia are debilitating treatment-resistant symptoms of depression. Depressed people show a bias towards the selection of low effort activities. To determine if the broadly used antidepressant fluoxetine ca...

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Bibliographic Details
Main Authors: Carratalá-Ros, C. (Author), Correa, M. (Author), López-Cruz, L. (Author), Martínez-Verdú, A. (Author), Olivares-García, R. (Author), Salamone, J.D (Author)
Format: Article
Language:English
Published: Frontiers Media S.A. 2021
Subjects:
adult
anergia
animal experiment
animal model
appetitive behavior
Article
aversive behavior
climbing
controlled study
depression
dopamine
drug effect
drug efficacy
effort
escape behavior
fluoxetine
food reinforcement
forced swim test
male
mental disease
motivation
mouse
nonhuman
serotonin
sucrose preference test
swimming
T-maze test
vigor
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