In utero Exposure to Valproic-Acid Alters Circadian Organisation and Clock-Gene Expression: Implications for Autism Spectrum Disorders

In utero Exposure to Valproic-Acid Alters Circadian Organisation and Clock-Gene Expression: Implications for Autism Spectrum Disorders

Autism Spectrum Disorder (ASD) is a pervasive neurodevelopmental disorder characterised by restrictive patterns of behaviour and alterations in social interaction and communication. Up to 80% of children with ASD exhibit sleep-wake cycle disturbances, emphasising the pressing need for novel approach...

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Bibliographic Details
Main Authors: Amir, S. (Author), Belforte, N. (Author), de Zavalia, N. (Author), Ferraro, S. (Author)
Format: Article
Language:English
Published: Frontiers Media S.A. 2021
Subjects:
animal experiment
animal model
animal tissue
Article
autism
autism spectrum disorder
BMAL1 gene
circadian rhythm
circadian rhythms
clock gene expression
clock-gene
controlled study
female
gene expression
immunofluorescence
immunohistochemistry
light dark cycle
male
nonhuman
prenatal exposure
rat
retina
rhythm disturbances
rodent model
running
sex difference
suprachiasmatic nucleus
transcription factor ARNTL
valproic acid
Western blotting
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