Early Enhancement of Neuroplasticity Index, the Ratio of Serum Brain-Derived Neurotrophic Factor Level to HAMD-24 Score, in Predicting the Long-Term Antidepressant Efficacy

Early Enhancement of Neuroplasticity Index, the Ratio of Serum Brain-Derived Neurotrophic Factor Level to HAMD-24 Score, in Predicting the Long-Term Antidepressant Efficacy

Background: Current mainstream treatment of major depressive disorder (MDD) has a disadvantage in delayed onset of efficacy, making detection of early signatures predicative of the long-term treatment efficacy urgent. Methods: MDD patients were scored with HAMD-24 and serum brain-derived neurotrophi...

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Bibliographic Details
Main Authors: Chen, G. (Author), Chen, Z. (Author), Cui, B. (Author), Lu, Y. (Author), Miao, J. (Author), Wang, H. (Author), Wang, T. (Author), Yuan, Y. (Author), Zhang, Y. (Author), Zhao, X. (Author), Zou, Z. (Author)
Format: Article
Language:English
Published: Frontiers Media S.A. 2021
Subjects:
adult
antidepressant activity
antidepressant efficacy
Article
BDNF
controlled study
double blind procedure
drug efficacy
drug megadose
escitalopram
evening dosage
female
Hamilton Depression Rating Scale
herbaceous agent
human
low drug dose
major clinical study
major depression
male
middle aged
monotherapy
nervous system parameters
neuroplasticity index
open study
parallel design
placebo
prediction
predictive value
prospective study
protein blood level
randomized controlled trial
receiver operating characteristic
sensitivity and specificity
treatment outcome
unclassified drug
yueju
Yueju pill
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