Puerarin Alleviates Vascular Cognitive Impairment in Vascular Dementia Rats

Puerarin Alleviates Vascular Cognitive Impairment in Vascular Dementia Rats

Cerebral ischemia triggers vascular dementia (VD), which is characterized by memory loss, cognitive deficits, and vascular injury in the brain. Puerarin (Pur) represents the major isoflavone glycoside of Radix Puerariae, with verified neuroprotective activity and cardiovascular protective effects. H...

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Bibliographic Details
Main Authors: Huang, N. (Author), Li, P. (Author), Qiu, Y. (Author), Song, P. (Author), Wan, G. (Author), Wang, S. (Author), Wu, Z. (Author), Xu, J. (Author), Yin, Y. (Author), Zhu, M. (Author), Zhu, T. (Author)
Format: Article
Language:English
Published: Frontiers Media S.A. 2021
Subjects:
animal experiment
animal model
animal tissue
Article
cell loss
cognitive defect
cognitive impairment (dementia)
dose response
drug effect
drug mechanism
hippocampal CA1 region
malonaldehyde
multiinfarct dementia
n methyl dextro aspartic acid receptor
n methyl dextro aspartic acid receptor 2A
nerve cell
nerve cell plasticity
nonhuman
NR2A
oxidative stress
protein Bax
protein bcl 2
puerarin
rat
reactive oxygen metabolite
ROS
signal transduction
superoxide dismutase
transient receptor potential channel M3
TRPM2
vascular dementia
vasodilatation
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