Chronic Distress in Male Mice Impairs Motivation Compromising Both Effort and Reward Processing With Altered Anterior Insular Cortex and Basolateral Amygdala Neural Activation

Chronic Distress in Male Mice Impairs Motivation Compromising Both Effort and Reward Processing With Altered Anterior Insular Cortex and Basolateral Amygdala Neural Activation

In humans and mammals, effort-based decision-making for monetary or food rewards paradigms contributes to the study of adaptive goal-directed behaviours acquired through reinforcement learning. Chronic distress modelled by repeated exposure to glucocorticoids in rodents induces suboptimal decision-m...

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Bibliographic Details
Main Authors: Cabeza, L. (Author), Cramoisy, S. (Author), Fellmann, D. (Author), Haffen, E. (Author), Houdayer, C. (Author), Peterschmitt, Y. (Author), Ramadan, B. (Author), Risold, P.-Y (Author)
Format: Article
Language:English
Published: Frontiers Media S.A. 2021
Subjects:
adult
animal cell
animal experiment
animal tissue
Article
basolateral amygdala
C57BL 6 mouse
cell activation
chronic distress
concentration (parameter)
conditioned response anxiety test
controlled study
corticosterone
decision making
distress syndrome
effort
food deprivation
free feeding test
glucocorticoids
immunohistochemistry
insula
insular cortex
male
motivation
mouse
nonhuman
novelty suppressed feeding test
operant behavioral test
reinforcement (psychology)
reward
reward processing
sucrose preference test
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